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Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder and as an aid to stopping smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and have at least one weight-related health.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical exercise. Results from a clinical study that enrolled patients without diabetes indicated that patients had an average weight loss of 4.1% in contrast to participants who were given placebos) during a 12- month period, while a separate study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at one full year. Using two separate drugs to lose weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight loss and the those who go through it one should err assisting caution and let the FDA do its job and demand some research be done in order that the public is aware of the side effects and risks of the medications before we bring them. Keep in mind that drug companies come in business to generate money and that they would say almost anything to keep people on their medications. Researchers found that participants taking this drug for a year, lost excess weight within one month and have kept the body weight off through the 56 weeks from the study. Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which are made up of many active ingredient, which may make them far better and safer. Combo-pilling is the newest fad or in addition to this the newest in the future under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular will be the fact that as of right now there are not any long term prescription diet pills that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug also can raise blood pressure levels and heartrate, and mustn't be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must stop used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients to the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking. A pyromaniac, with both psychiatric and medical therapy, can still be treated. It is best completed with behavioral therapy. Psychotherapy treatment alongside behavior modification is regarded as the frequently used treatment. Based on the study of Jon Grant, a compounding treatment of drugs and behavioral therapy was discovered to be successful in treating pyromania. The utilization of serotonin reuptake inhibitors is also beneficial in governing the impulsive behavior from the patient like other impulse control disorder. Also great for the patient are medications like Lithium, naltrexone, (ReVia), fluoxetine (Prozac), citalopram (Celexa), paroxetene (Paxil), along with other antidepressants.