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Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that at the time of right now there are not any long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure and pulse rate, and really should not be used in people who have a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high hypertension, in addition to by a person with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. 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